ea0070ep516 | Thyroid | ECE2020
Ryom Riis Kamilla
, Larsen Camilla
, Winther Kristian H.
, Larsen Emil L.
, Ellervik Christina
, Hegedüs Laszlo
, Brix Thomas
, Poulsen Henrik E.
, Bonnema Steen J.
Background: Hyperthyroidism as well as hypothyroidism have been associated with oxidative stress, caused by an imbalance between pro-oxidants and antioxidants. Oxidative stress may damage the genomic apparatus and other cellular structures. Urinary excretion of 8-oxo-7.8-dihydroguanosine (8-oxoGuo) and 8-oxo-7.8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent global RNA and DNA oxidation, thus reflecting oxidatively generated modification of nucleic acids in...